Paris Saint-Germain's dreams of defending its domestic treble are beginning to fade after the champions slumped to a 3-1 defeat at Nice in the French league on Sunday, finishing the match with only nine men.
Robert Lewandowski scored twice as Bayern Munich ensured a record fifth straight Bundesliga title with a 6-0 rout of Wolfsburg on Saturday.
Patrik Schick scored another goal as his Sampdoria side drew 1-1 at Torino on Saturday in Serie A.
No escapes this year, Sunderland is leaving the Premier League.
Barcelona and Real Madrid maintained their neck-and-neck title race in the Spanish league on Saturday, when both teams won to stay level on points at the top.
Serie A leader Juventus was held by host Atalanta to 2-2 on Friday.
Wissam Ben Yedder scored three minutes after entering the game to give Sevilla a late 2-1 win over 10-man Celta Vigo in the Spanish league on Thursday.
Manchester United held on following Marouane Fellaini's late sending-off for headbutting Sergio Aguero to draw 0-0 at Manchester City in the English Premier League on Thursday, keeping the race for Champions League qualification congested.
For only the third time in its 135-year existence, Tottenham is enjoying an eight-match winning run in the league after edging past Crystal Palace 1-0 on Wednesday.
While Lionel Messi helped Barcelona trounce Osasuna 7-1, Cristiano Ronaldo was rested by title rival Real Madrid in its 6-2 rout of Deportivo La Coruna in the Spanish league on Wednesday.