Nadal, a two-time champ, came back from two sets down but couldn't prevail in an epic struggle that took almost five hours.
Meanwhile, Novak Djokovic lived up to his second seeding as he mowed down Adam Pavlasek.
Federer, seeking an eighth title at the All England club, advanced 6-3, 3-0 when Alexandr Dolgopolov quit with a foot injury.
Roger Federer confirms his decision to skip the entire clay season this spring will have served him well in his quest for an eighth Wimbledon title.
Marin Cilic and Sam Querrey step closer to repeat titles in key Wimbledon warmup event.
Five-time Queen's club winner Andy Murray sees luck run out, losing to Australian Jordan Thompson.
King of clay Rafael Nadal hammers Stan Wawrinka 6-2, 6-3, 6-1 to earn an unprecedented 10th title at the French Open on Sunday.
Right from the start of the French Open final, Jelena Ostapenko made quite clear to anyone unfamiliar with her name, or her game, what she is all about.
Maria Sharapova reveals that she will be forced to miss the entire grass court season due to a thigh muscle tear, dealing a blow to her immediate comeback hopes after serving a 15-month doping ban.
Jelena Ostapenko is a young woman in a hurry.