Germany, England and Poland all took another step toward World Cup qualification but the Netherlands' failure to do the same cost national coach Danny Blind his job on Sunday.
The Netherlands' hopes of reaching the World Cup finals suffered a major setback on Saturday when the three-time runners-up slumped to a shock 2-0 defeat to Bulgaria.
Halfway through European qualifying for the 2018 World Cup, there is little to divide some of the teams.
Marcello Lippi earned his biggest win since taking over as coach of China, 1-0 against South Korea in a World Cup qualifier on Thursday.
Brazil was not intimidated by more than 60,000 raucous fans at the Estadio Centenario in Montevideo, beating second-place Uruguay 4-1 in South America's World Cup qualifying group to retain the lead in the standings after 13 matches.
In his last international game in a 13-year career, Lukas Podolski struck a brilliant winning goal to sign off by giving Germany a 1-0 win over England in a friendly on Wednesday.
Marcello Lippi faces his biggest challenge as China coach, needing a win against South Korea to keep alive any hopes of qualifying for Russia 2018.
Lionel Messi scored his 40th and 41st goals in all competitions this season to lead Barcelona to a 4-2 victory over 10-man Valencia in the Spanish league on Sunday.
Joe Hart gifted Internazionale both of its goals but Torino managed to draw 2-2 in Serie A on Saturday and damage Inter's bid for a Champions League place.
Cristiano Ronaldo turned into Real Madrid's playmaker by setting up two goals to beat Athletic Bilbao 2-1 on Saturday and keep on track to reclaim the Spanish league title.