Cubs 4, Padres 0 Ryan Dempster struck out a career-high 12 and hit a go-ahead single against Greg Maddux during a four-run fifth inning at Chicago, leading the Cubs over the Padres.

Jim Edmonds singled in his debut with the Cubs, who won three of four from the team with the worst record in the major leagues (15-27). NL Central-leading Chicago has won six of seven.

Dempster (5-1) allowed six hits in 8 1-3 innings and walked one, leaving after 115 pitches. He retired 15 straight batters after a first-inning single by Brian Giles, who had three hits.

Maddux (3-4), who entered the major leagues with the Cubs in 1986, made what might have been his final start at Wrigley Field. He allowed four runs and 11 hits in 4 1-3 innings.

Astros 8, Giants 7 At San Francisco, Lance Berkman splashed his major league-leading 15th home run into McCovey Cove, breaking a ninth-inning tie and helping Houston rally past the Giants.

Houston came back from a 6-0 deficit to take three of four from the Giants, its first series win at San Francisco since a three-game sweep in September 2001.

Pinch-hitter Darin Erstad hit a tying, three-run homer in the eighth and Carlos Lee also homered in the inning off Tyler Walker, who faltered on his 32nd birthday. Berkman connected off Vinnie Chulk (0-2) for the first splash-hit homer by an Astro.

Tim Byrdak (2-0) got two outs for the win and Jose Valverde struck out two in a perfect ninth for his 11th save in 14 opportunities. Byrdak hasn’t allowed a run in 11 outings.

Phillies 5, Braves 0 At Philadelphia, Cole Hamels pitched his first career shutout, Ryan Howard homered and the Phillies moved within a game of the NL East-leading Florida Marlins.

Pedro Feliz and Shane Victorino also homered and drove in two runs each for the Phillies, who lead the major leagues with 59 home runs. Florida has hit 58.

Hamels (5-3) gave up just four hits, struck out six and walked two in his first complete game of the season. Only two runners reached second base against Hamels, who has lasted at least seven innings in eight of his nine starts this season.

All three Phillies homers came against Braves starter Chuck James (2-3), who allowed the five runs on six hits and five walks over four shaky innings.

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