Gagne earned his 10th save, but it wasn’t easy. Gagne allowed a leadoff single to Russell Martin before getting Blake DeWitt to hit into a fielder’s choice and Mark Sweeney to fly out. DeWitt advanced to second on a passed ball, and Gagne walked Andruw Jones before getting Juan Pierre to pop out to end the game.

Coming off one of the worst outings of his career last week, Los Angeles starter Brad Penny (5-4) gave up two runs in the first four innings, then got in trouble in the fifth after issuing a leadoff four-pitch walk to Brewers pitcher Carlos Villanueva (2-4).

Pirates 8, Cardinals 4, 10 innings At St. Louis, Ronny Paulino drove in the go-ahead run in a four-run 10th inning to lead Pittsburgh over St. Louis for its seventh win in eight games.

Adam LaRoche added a three-run double off Ron Villone (1-1) in the 10th for the Pirates, who are one game below .500. Nate McLouth hit a two-run homer and Paulino, who entered in the second after catcher Ryan Doumit hurt his left thumb muffing a pitch on a passed ball in the first, hit a tying double in the seventh.

Troy Glaus hit a three-run homer and Albert Pujols tied it in the eighth for the Cardinals. Pujols, who had a day off Monday, also walked twice and has reached base in all 40 games.

Giants 4, Astros 2 At San Francisco, Matt Cain hit a solo home run and earned his first victory in three starts, and San Francisco snapped Houston’s four-game winning streak.

It was the fourth career homer and second this season for Cain (2-3), whose drive to left leading off the fifth put the Giants up 4-1. He also connected on April 12 against St. Louis.

Omar Vizquel and Randy Winn hit back-to-back RBI doubles in the first as the Giants jumped to an early lead on the way to handing Houston its second loss in 11 games.

Carlos Lee hit his eighth home run in the eighth inning for Houston.

Diamondbacks 8, Rockies 4 At Phoenix, Randy Johnson went five shaky innings for his 287th career victory, backed by Stephen Drew’s three-run homer in Arizona’s win over Colorado.

The Big Unit (3-1) gave up four runs and nine hits, striking out four and walking none.

Chris Young had three hits as the Diamondbacks hammered Colorado starter Jeff Francis (0-4), a 17-game winner for the National League champions a year ago.

Garrett Atkins hit his seventh homer and Ryan Spilborghs doubled twice for the Rockies, who fell nine games behind the NL West leaders.

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