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Drug trial results in reduction of HIV in gay men

WASHINGTON--A daily dose of an oral antiretroviral drug reduced the number of HIV infections among sexually active gay men by 44 percent, a U.S. study carried out on four continents said Tuesday.

The study was conducted among 2,499 men, including 29 transgendered women, between the ages of 18 and 67 who were sexually active with other men but were not infected with the virus that causes AIDS.

The iPrEx HIV Prevention Study was carried out from July 2007 to December 2009 in six countries — Brazil, Ecuador, Peru, South Africa, Thailand and the United States — and the results will be published in the Nov. 25 issue of the New England Journal of Medicine.

Participants were selected at random to take a daily dose of Truvada — a combination of 200 milligrams of emtricitabine and 300 milligrams of tenofovir disoproxil fumarate — or a placebo.

All participants were given counseling on preventing the spread of the virus as well as condoms and medical care for other sexually-transmitted diseases during the course of the study.

A total of 100 HIV infections were recorded among the participants during the nearly three-year-long clinical study.

Of those, 36 were recorded among the 1,251 participants given Truvada and 64 of the 1,248 who had been given a placebo, showing that the drug reduced the risk of infection by 43.8 percent, according to the authors of the study.

Anthony Fauci, the director of the National Institute of Allergy and Infectious Diseases (NIAID), which carried out the study, called the results “significant.”

“Those who took the drug on 90 percent or more days had 72.8 percent fewer HIV infections,” he told AFP.

NIAID sponsored much of the study, with additional funds provided by the Bill and Melinda Gates Foundation. California-based Gilead Sciences, which makes Truvada, donated the drugs used in the study.

Those who carried out the study were concerned that participants would be less cautious, thinking they were protected by the drugs, but instead the subjects reported increased use of condoms and fewer sexual partners.

Gay men are one of the most at-risk groups for HIV in the United States, accounting for more than half of the 56,000 new infections each year.

One in five gay men living in 21 major U.S. cities is infected with HIV and nearly half are unaware of it, the Centers for Disease Control and Prevention (CDC) said in a study published in September.

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