WHO meets on production of H1N1 vaccine

Pharmaceutical companies are ready to begin making a swine flu vaccine — but as the virus may mutate, questions abound: How much should be produced? How will it be distributed? Who should get it?

The expert group's recommendations will be passed to WHO Director-General Margaret Chan, who is expected to issue advice to vaccine manufacturers and the World Health Assembly next week.

WHO's flu chief said the meeting of industry representatives and independent experts sought to answer questions including when to recommend to manufacturers that they switch from a seasonal vaccine to one that works against the pandemic strain.

“No big decisions, no announcements,” Keiji Fukuda told reporters after the meeting. “These are enormously complicated questions, and they are not something that anyone can make in a single meeting.”

But some feel the main decision has already been made.

“It's a foregone conclusion,” said David Fedson, a vaccines expert and former professor of medicine at the University of Virginia. “If we don't invest in an H1N1 (swine flu) vaccine, then possibly we could have a reappearance of this virus in a mild, moderate, or catastrophic form and we would have absolutely nothing.”

Most flu vaccine companies can only make one vaccine at a time: seasonal flu vaccine or pandemic vaccine. Production takes months and it is impossible to switch halfway through if health officials make a mistake.

Vaccine makers can make limited amounts of both seasonal flu vaccine and pandemic vaccine — though not at the same time — but they cannot make massive quantities of both because that exceeds manufacturing capacity.

“What is really going to be wrestled with is that seasonal influenza itself has a significant impact on people,” said Fukuda. “This is an infection which is estimated to kill some hundreds of thousands of people each year around the world, so there is a real trade-off if you just say we're going to stop making that vaccine.”

WHO estimates that up to 2 billion doses of swine flu vaccine could be produced every year, though the first batches wouldn't be available for four to six months. While the vaccine question hangs in the air, WHO has given Indian pharmaceuticals giant Cipla the medical go-ahead to produce a generic version of the anti-viral medication Tamiflu. The drug, also known as oseltamivir, is one of two anti-virals shown to work against swine flu.

Subscribe to The China Post and save 25%. Click here

SharePrintEmail

Write a Comment

Terms

Enter your comments - 3000 characters max

Type in image code

Submit

 Receive China Post promos
 Respond to this email