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June 29, 2017

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Neanderthal DNA more common than thought

WASHINGTON--Next time you call someone a Neanderthal, better look in a mirror. Many of the genes that help determine most people's skin and hair are more Neanderthal than not, according to two new studies that look at the DNA fossils hidden in the modern human genome.

About 50,000 years ago, modern day humans migrated out of Africa north to Europe and East Asia and met up with furrow-browed Neanderthals that had been in the colder climates for more than 100,000 years. Some of the two species mated. And then the Neanderthals died off as a species — except for what's left inside of us.

Scientists isolated the parts of the modern human genetic blueprint that still contain Neanderthal remnants. Overall, it's barely more than 1 percent, said two studies released Wednesday in the journals Nature and Science.

However, in some places, such as the DNA related to the skin, the genetic instructions are as much as 70 percent Neanderthal and in other places there's virtually nothing from the species that's often portrayed as brutish cavemen.

The difference between where Neanderthal DNA is plentiful and where it's absent may help scientists understand what in our genome "makes humans human," said University of Washington genome scientist Joshua Akey, lead author of the paper in Science.

The studies mostly examined the genomes of people whose ancestors left Africa at some point. People whose ancestors have all stayed in Africa have almost no Neanderthal DNA because there was little interbreeding.

Harvard University researcher Sriram Sankararaman, the lead author of the Nature study, said the place where Neanderthal DNA seemed to have the most influence in the modern human genome has to do with skin and hair. Akey said those instructions are as much as 70 percent Neanderthal.

"We're more Neanderthal than not in those genes," Akey said.

However, Sankararaman cautions that scientists don't yet know just what the Neanderthal DNA dictates in our skin and hair.

Sarah Tishkoff, a professor of genetics and biology at the University of Pennsylvania who was not part of either study, theorized that the Neanderthal DNA probably helped the darker humans out of Africa cope with the cooler less bright north. Living in the cooler Europe means less ultraviolet light and less vitamin D from the sun. Darker skin blocks more of those needed rays, so lighter skin is more advantageous in the north and it seems that humans adopted that Neanderthal adaptation, she said.

Another area where we have more Neanderthal DNA is parts of genetic codes that have to do with certain immune system functions, Sankararaman said. Again, scientists can't say more than that these Neanderthal genes seem connected to certain diseases, such as type 2 diabetes and Crohn's disease and lupus, but they are there.

Tiskhoff and Akey said one of the most interesting parts in comparing human and Neanderthal genomes is where we don't see any caveman influence. That, Tiskhoff said, is "what makes us uniquely human" and those regions of genetic code "you just can't mess with."

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