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New cervical cancer treatment hopes on horizon after origin cell discovery

WASHINGTON--Researchers have found the cells at the origin of cervical cancer, in a discovery that could offer new ways to prevent and treat the disease, according to a U.S.-published study on Monday.

Most cases of cervical cancer are known to be caused by specific strains of human papillomavirus, but now researchers know the specific group of cells that HPV targets, said the study in the Proceedings of the National Academy of Sciences.

Moreover, when they are removed from the cervix they do not appear to regenerate, said the study by scientists at Brigham and Women's Hospital, Harvard Medical School and the Agency for Science Technology and Research (A-STAR) in Singapore.

The cells can become cancerous when infected with HPV while other cells in the cervix often do not, said senior author Christopher Crum, director of women's and perinatal pathology at Brigham and Women's Hospital in Massachusetts.

They also have a particular gene expression that is the same as found in aggressive cervical tumors, which could allow doctors to differentiate benign lesions from dangerous pre-cancers.

“We have discovered a discrete population of cells that are located in a specific area of the cervix that could be responsible for most, if not all, of HPV-associated cervical cancers,” said Crum, who was joined by researchers Wa Xian from A-STAR and Frank McKeon of Harvard Medical School. Michael Herfs, a postdoctoral fellow at Brigham and Women's, was the lead author.

The cells are located near the opening of the cervix, in a transition area between the uterus and the vagina known as the squamo-columnar junction.

The findings build on the group's previous research that identified the origin of a rare and sometimes cancerous change in certain cells in the esophagus, at a junction between the tube that carries food through the throat and the stomach.

A similar population of cells has been found to reside in the cervix, Crum said. They are the remnants of a process known as embryogenesis, which is the process of cell division and growth that we all undergo in the process of growing from embryo to fetus.

“There is a population of cells in the cervix that during fetal life disappears and is replaced by another type. We found out that a small number of these cells are actually not lost and they remained there, almost like little sentinels from a prior age,” Crum told AFP.

“It appears that that particular group of remaining embryonic cells at the squamo-columnar junction is the population that you must infect, at least in the great majority of cases, to produce the significant cancers and precancers,” he added.

Knowing the biology of these cells and where they reside could help physicians both clarify which cervical precancers (dysplasias) need treatment and also possibly prevent cancer altogether by destroying the cells in advance.

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